SETD2 Mouse Monoclonal Antibody [Clone ID: OTI1E1]
SETD2 mouse monoclonal antibody, clone OTI1E1 (formerly 1E1)
Product Datasheet for 'TA804377'
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|Recommend Dilution||WB 1:2000, IHC 1:150|
|Immunogen||Human recombinant protein fragment corresponding to amino acids 1787-2144 of human SETD2 (NP_054878) produced in E.coli.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Gene Name||SET domain containing 2|
|Background||Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug|
|Synonyms||HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A; LLS; SET2; p231HBP|
|Protein Families||Druggable Genome|
|Protein Pathways||Lysine degradation|