SETD2 Mouse Monoclonal Antibody [Clone ID: OTI1E1]

CAT#: TA804377

SETD2 mouse monoclonal antibody, clone OTI1E1 (formerly 1E1)


 Product Datasheet for 'TA804377'

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USD 360.00


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Size
    • 100 ul


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Specifications

Product Data
Clone Name OTI1E1
Applications IHC, WB
Recommend Dilution WB 1:2000, IHC 1:150
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1787-2144 of human SETD2 (NP_054878) produced in E.coli.
Isotype IgG2a
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids by affinity chromatography
Gene Name SET domain containing 2
Background Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug
Synonyms HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A; LLS; SET2; p231HBP
Reference Data
Protein Families Druggable Genome
Protein Pathways Lysine degradation

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