SnoN (SKIL) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2F6]

CAT#: TA800171AM

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SKIL mouse monoclonal antibody,clone 2F6, Biotinylated



USD 509.00


Availability*
5 Days

Size
    • 100 ul


Specifications

Product Data
Clone Name OTI2F6
Applications IHC, WB
Recommended Dilution WB 1:500~2000, IHC 1:150
Reactivities Human, Monkey, Mouse, Rat, Dog
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 307-684 of human SKIL (NP_005405) produced in E.coli.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Biotin
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 76.8 kDa
Gene Name SKI-like proto-oncogene
Background The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms SNO; SnoA; SnoI; SnoN
Reference Data
Protein Families Druggable Genome, Transcription Factors
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