PGP9.5 (UCHL1) Biotinylated Rabbit Monoclonal Detection Antibody (Biotin conjugated) [Clone ID: OTIR2F11]

SKU TA700568

UCHL1 biotinylated rabbit monoclonal antibody, clone OTIR2F11

Product Data

• Clone Name: OTIR2F11
• Application: ELISA
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within human UCHL1 (NP_004172). The exact sequence is proprietary.
• Buffer: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Biotin
• Shipping: Blue Ice
• Predicted Protein Size: 24.8 kDa
• Gene Name: ubiquitin C-terminal hydrolase L1
• Database Link:
  NP_004172
  P09936
• Background: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons, expressed specifically in neurons and testis/ovary. UCHL1 has been proposed as a candidate biomarker for brain injury. Baseline levels of the biomarker UCHL1 measured in cerebral spinal fluid (CSF) are predictive of long-term multiple sclerosis (MS) progression. Recent studies have demonstrated that UCHL1 could be a potential biomarker for multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, aggressive multiple myeloma and for discriminating the Parkinson’s disease.
• Synonyms: HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; Uch-L1
• Matched ELISA Pair: TA600568

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease