Papillary renal cell carcinoma (PRCC) Rabbit Polyclonal Antibody

CAT#: TA590344

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Rabbit Polyclonal PRCC Antibody



USD 482.00

In Stock*

Size
    • 100 ug

Frequently bought together (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 200.00

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
Reactivities Human, Monkey, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Formulation 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Concentration 1.14mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name proline rich mitotic checkpoint control factor
Background In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.
Synonyms MGC4723; MGC17178; OTTHUMP00000038719; papillary renal cell carcinoma (translocation-associated); papillary renal cell carcinoma translocation-associated gene product; proline-rich protein PRCC; RCCP1; TPRC
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
Reference Data
Protein Families Druggable Genome
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