Papillary renal cell carcinoma (PRCC) Rabbit Polyclonal Antibody

CAT#: TA590344

Rabbit Polyclonal PRCC Antibody

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY PRCC (Cat# [RC223284], Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRCC(Cat# TA590344).

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  Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PRCC polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

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  Western Blot: PRCC Antibody

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  ELISA: PRCC Antibody

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  Immunohistochemical staining of paraffin-embedded Human colon tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

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  Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

• Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)

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Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
• Reactivities: Human, Monkey, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 1.14mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: proline rich mitotic checkpoint control factor
• Database Link:
  NP_955448
  Entrez Gene 94315 MouseEntrez Gene 718660 MonkeyEntrez Gene 5546 Human
  UniProt ID Q92733
• Background: In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.
• Synonyms: MGC4723; MGC17178; OTTHUMP00000038719; papillary renal cell carcinoma (translocation-associated); papillary renal cell carcinoma translocation-associated gene product; proline-rich protein PRCC; RCCP1; TPRC
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Druggable Genome