IDO1 Mouse Monoclonal Antibody [Clone ID: OTI2G4]

CAT#: TA506367

IDO1 mouse monoclonal antibody, clone OTI2G4 (formerly 2G4)

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 Product Datasheet for 'TA506367'

USD 379.00

In Stock

    • 100 ul

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Product Data
Clone Name OTI2G4
Applications WB, IHC, IF
Recommend Dilution WB 1:200~2000, IHC 1:150, IF 1:100,
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human IDO1(NP_002155) produced in HEk293T cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1.00mg/ml
Purification Purified from cell culture supernatant by affinity chromatography
Predicted Protein Size 45.1 kDa
Gene Name indoleamine 2,3-dioxygenase 1
Background This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].
Synonyms IDO|IDO-1|INDO
Reference Data
Protein Families Druggable Genome
Protein Pathways Tryptophan metabolism, Metabolic pathways
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