MDMX (MDM4) Mouse Monoclonal Antibody [Clone ID: OTI4B5]

CAT#: TA505706

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MDM4 (MDMX) mouse monoclonal antibody, clone OTI4B5 (formerly 4B5)



  View other "OTI4B5" antibodies (4)

Special Offer: Try sample size of this antibody at $99/€99. Use code “TrueSample”.

USD 417.00


Availability*
In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name OTI4B5
Applications IF, IHC, WB
Recommended Dilution WB 1:200~2000, IHC 1:150, IF 1:100
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human MDM4(NP_002384) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 54.7 kDa
Gene Name MDM4 regulator of p53
Background This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Synonyms HDMX; MDMX; MRP1
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways p53 signaling pathway

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