RAMP2 Mouse Monoclonal Antibody [Clone ID: OTI4E5]
RAMP2 mouse monoclonal antibody, clone OTI4E5 (formerly 4E5)
Product Datasheet for 'TA504410'
|Applications||FC, IHC, WB|
|Recommend Dilution||WB 1:1000, IHC 1:150, FLOW 1:100|
|Immunogen||Full length human recombinat protein of human RAMP2(NP_005845) produced in HEK293T cell.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||15.8 kDa|
|Gene Name||receptor activity modifying protein 2|
|Background||The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq]|
|Protein Families||Druggable Genome, Transmembrane|
|Protein Pathways||Vascular smooth muscle contraction|
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