JAB1 (COPS5) Mouse Monoclonal Antibody [Clone ID: OTI2B12]

CAT#: TA504344

COPS5 (JAB1) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY COPS5 (Cat# RC200979, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS5(Cat# TA504344). Positive lysates LY416392 (100ug) and LC416392 (20ug) can be purchased separately from OriGene.

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  Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

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  Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-COPS5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA504344)

• Anti-COPS5 mouse monoclonal antibody (TA504344) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY COPS5 (RC200979).

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Specifications

Product Data

• Clone Name: OTI2B12
• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:2000, IHC 1:150, IF 1:100
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human COPS5(NP_006828) produced in HEK293T cell.
• Formulation: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.76 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 37.4 kDa
• Gene Name: COP9 signalosome subunit 5
• Database Link:
  NP_006828
  Entrez Gene 26754 MouseEntrez Gene 312916 RatEntrez Gene 10987 Human
  UniProt ID Q92905
• Background: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq]
• Synonyms: CSN5; JAB1; MOV-34; SGN5

Reference Data

• Protein Families: Druggable Genome, Protease, Transcription Factors