GMDS Mouse Monoclonal Antibody [Clone ID: OTI2A1]

CAT#: TA502141

GMDS mouse monoclonal antibody, clone OTI2A1 (formerly 2A1)

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY GMDS (Cat# RC200471, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GMDS(Cat# TA502141). Positive lysates LY419903 (100ug) and LC419903 (20ug) can be purchased separately from OriGene.

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  Western blot analysis of extracts (10ug) from a mouse tissue by using anti-GMDS monoclonal antibody (1:200).

Specifications

Product Data

• Clone Name: OTI2A1
• Applications: WB
• Recommended Dilution: WB 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human GMDS (NP_001491) produced in HEK293T cell.
• Formulation: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.64 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 41.8 kDa
• Gene Name: GDP-mannose 4,6-dehydratase
• Database Link:
  NP_001491
  Entrez Gene 2762 Human
  UniProt ID O60547
• Background: GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020). [supplied by OMIM]
• Synonyms: GMD; SDR3E1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism, Metabolic pathways