PKA R2 (PRKAR2A) Mouse Monoclonal Antibody [Clone ID: OTI1F8]
PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1F8 (formerly 1F8)
Product Datasheet for 'TA501146'
Use code "SUMMER" to get 40% off list price.
|Applications||FC, IF, IHC, WB|
|Recommend Dilution||WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100|
|Immunogen||Full length human recombinant protein of human PRKAR2A (NP_004148) produced in HEK293T cell.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Predicted Protein Size||45.3 kDa|
|Gene Name||protein kinase cAMP-dependent type II regulatory subunit alpha|
|Background||cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq].|
|Protein Families||Druggable Genome|
|Protein Pathways||Apoptosis, Insulin signaling pathway|