L1CAM Mouse Monoclonal Antibody [Clone ID: OTI3G1]
L1CAM mouse monoclonal antibody, clone OTI3G1 (formerly 3G1)
Product Datasheet for 'TA500792'
|Applications||FC, IF, IHC, IP, WB|
|Recommend Dilution||WB 1:1000, IHC 1:50, IF 1:100, FLOW 1:100, IP 2-4ug/mg|
|Immunogen||Full length human recombinant protein of human L1CAM (NP_000416) produced in HEK293T cell.|
|Formulation||PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||140.0 kDa|
|Gene Name||L1 cell adhesion molecule|
|Background||The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.|
|Synonyms||CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Transmembrane|
|Protein Pathways||Axon guidance, Cell adhesion molecules (CAMs)|
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