TSG101 Rabbit Monoclonal Antibody [Clone ID: R01-9A7]
| Product Data | |
| Clone Name | R01-9A7 |
|---|---|
| Application | IP, WB |
| Recommended Dilution | WB: 1/2000 IP: 1/20 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human TSG101 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 44 kDa; Observed MW: 44 kDa |
| Gene Name | tumor susceptibility 101 |
| Database Link | |
| Background | Swiss-Prot Acc.Q99816.Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). |
| Synonyms | TSG10; VPS23 |
| Reference Data | |
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