COX2 (PTGS2) Rabbit Monoclonal Antibody [Clone ID: R04-3I1]
| Product Data | |
| Clone Name | R04-3I1 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB: 1/1000 IHC: 1/20 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human COX2 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 69 kDa; Observed MW: 69 kDa |
| Gene Name | prostaglandin-endoperoxide synthase 2 |
| Database Link | |
| Background | Swiss-Prot Acc.P35354.Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. |
| Synonyms | COX-2; COX2; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2 |
| Reference Data | |
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