APPBP1 (NAE1) Rabbit Monoclonal Antibody [Clone ID: R03-1A7]
| Product Data | |
| Clone Name | R03-1A7 |
|---|---|
| Application | IP, WB |
| Recommended Dilution | WB: 1/1000-1/2000 IP: 1/20 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human APPBP1 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 60 kDa; Observed MW: 60 kDa |
| Gene Name | NEDD8 activating enzyme E1 subunit 1 |
| Database Link | |
| Background | Swiss-Prot Acc.Q13564.Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. |
| Synonyms | A-116A10.1; APP-BP1; APPBP1; HPP1; ula-1 |
| Reference Data | |
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