MIB1 Rabbit Monoclonal Antibody [Clone ID: R06-3D9]

CAT#: TA384779

MIB1 Rabbit monoclonal Antibody

Product Images

Western blot analysis of Mib1/Mindbomb in K562, Hela lysates using MIB1 antibody.

Specifications

Product Data

• Clone Name: R06-3D9
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Mib1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 110 kDa; Observed MW: 110 kDa
• Gene Name: mindbomb E3 ubiquitin protein ligase 1
• Database Link:
  Entrez Gene 57534 Human
  UniProt ID Q86YT6
• Background: Swiss-Prot Acc.Q86YT6.E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
• Synonyms: DIP-1; DIP1; DKFZp686I0769; DKFZp761M1710; FLJ90676; KIAA1323; MGC129659; MGC129660; MIB; ZZANK2; ZZZ6