HDAC8 Rabbit Monoclonal Antibody [Clone ID: R03-4G9]
| Product Data | |
| Clone Name | R03-4G9 |
|---|---|
| Application | IP, WB |
| Recommended Dilution | WB: 1/2000-1/10000 IP: 1/20 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human HDAC8 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 42 kDa; Observed MW: 42 kDa |
| Gene Name | histone deacetylase 8 |
| Database Link | |
| Background | Swiss-Prot Acc.Q9BY41.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. |
| Synonyms | CDA07; HD8; HDACL1; RPD3 |
| Reference Data | |
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