ATG16L1 Rabbit Monoclonal Antibody [Clone ID: R03-4G8]

CAT#: TA383763

ATG16L1 Rabbit monoclonal Antibody

Product Images

Western blot analysis of ATG16L1 in Hela, PC-12 lysates using ATG16L1 antibody.

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  Western blot analysis of ATG16L1 in 3T3 lysates using ATG16L1 antibody.

Specifications

Product Data

• Clone Name: R03-4G8
• Applications: WB
• Recommended Dilution: WB: 1/1000-1/2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human ATG16L1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 68 kDa; Observed MW: 68 kDa
• Gene Name: autophagy related 16 like 1
• Database Link:
  Entrez Gene 55054 Human
  UniProt ID Q676U5
• Background: Swiss-Prot Acc.Q676U5.Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
• Synonyms: APG16L; ATG16L; FLJ00045; FLJ10035; FLJ10828; FLJ22677; IBD10; WDR30