TIGIT Mouse Monoclonal Antibody [Clone ID: 4A11]

SKU TA355123

Mouse Monoclonal Anti-TIGIT Antibody [4A11]

Product Data

• Clone Name: 4A11
• Application: FC, IF, IHC, WB
• Recommended Dilution: IHC start at 2 ug/mL. IF start at 1 ug/mL. FC start at 1 ug/mL. ICC start at 1 ug/mL. WB start at 1 ug/mL.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT
• Buffer: TIGIT Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TIGIT Antibody is supplied as protein A purified IgG1.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 26 kDa; Observed: 47 kDa
• Gene Name: T-cell immunoreceptor with Ig and ITIM domains
• Database Link:
  NP_776160
  Q495A1
• Background: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses .Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer.
• Synonyms: DKFZp667A205; FLJ39873; VSIG9; VSTM3; WUCAM

Reference Data