B7H3 (CD276) Rabbit Polyclonal Antibody

CAT#: TA355034

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Rabbit Polyclonal Anti-CD276 Antibody

USD 484.00

5 Days

    • 100 ug

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Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 0.5-1µg/mL.IHC: 2µg/mL. Immunoflorescence start at 20µg/mL.
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen CD276 antibody was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of CD276. The immunogen is located within amino acids 484 - 534 of CD276.
Formulation CD276 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification CD276 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 35, 43, 57 kDa; Observed: 59 kDa
Gene Name CD276 molecule
Background CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
Synonyms 4Ig-B7-H3; B7-H3; B7H3
Note CD276 antibody can be used for Western blot at 0.5 - 1 µg/mL. Antibody can also be used for Immunohistochemistry at 2 µg/mL. For Immunoflorescence start at 20 µg/mL.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
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