MLK3 (MAP3K11) Rabbit Polyclonal Antibody

CAT#: TA351404

Rabbit Polyclonal Anti-MAP3K11 Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane 1-2: LO2 and PC-3 cell lysates Primary antibody: TA351404 (MAP3K11 Antibody) at dilution 1/400 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 5 minutes

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA351404 (MAP3K11 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA351404 (MAP3K11 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA351404 (MAP3K11 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA351404 (MAP3K11 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: MCF7, PC3, LO2, NIH/3T3 cell lysates
  IHC: 50-200
  Positive control: Human colorectal cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human MAP3K11
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 93 kDa
• Gene Name: mitogen-activated protein kinase kinase kinase 11
• Database Link:
  NP_002410
  Entrez Gene 26403 MouseEntrez Gene 309168 RatEntrez Gene 4296 Human
  UniProt ID Q16584
• Background: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
• Synonyms: MEKK11; MLK-3; MLK3; PTK1; SPRK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway