RNF20 Rabbit Polyclonal Antibody

CAT#: TA350359

Rabbit Polyclonal Anti-RNF20 Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane 1-6: Lovo cells A172 cells A375 cells 231 cells Jurkat cells hela cells Primary antibody: TA350359 (RNF20 Antibody) at dilution 1/350 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 seconds

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA350359 (RNF20 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA350359 (RNF20 Antibody) at dilution 1/25, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Lovo, A172, A375, 231, Jurkat and hela cells
  IHC: 20-100
  Positive control: Human esophagus cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human RNF20
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 114 kDa
• Gene Name: ring finger protein 20
• Database Link:
  NP_062538
  Entrez Gene 109331 MouseEntrez Gene 56254 Human
  UniProt ID Q5VTR2
• Background: The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor.
• Synonyms: BRE1; BRE1A; hBRE1

Reference Data

• Protein Families: Druggable Genome