MyoGEF (PLEKHG6) Rabbit Polyclonal Antibody

CAT#: TA350195

Rabbit Polyclonal Anti-PLEKHG6 Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane: 231 cells Primary antibody: TA350195 (PLEKHG6 Antibody) at dilution 1/800 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA350195 (PLEKHG6 Antibody) at dilution 1/45 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA350195 (PLEKHG6 Antibody) at dilution 1/45, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA350195 (PLEKHG6 Antibody) at dilution 1/45 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA350195 (PLEKHG6 Antibody) at dilution 1/45, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: 231 cells
  IHC: 100-300
  Positive control: Human lung cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human PLEKHG6
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 89 kDa
• Gene Name: pleckstrin homology and RhoGEF domain containing G6
• Database Link:
  NP_060643
  Entrez Gene 55200 Human
  UniProt ID Q3KR16
• Background: PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
• Synonyms: MyoGEF