PTPN5 Rabbit Polyclonal Antibody

SKU TA349114

Rabbit Polyclonal Anti-PTPN5 Antibody

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PTPN5 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 62 kDa; Observed: 60 kDa
• Gene Name: protein tyrosine phosphatase, non-receptor type 5
• Database Link:
  NP_008837
  Q9BZE0
• Background: The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).
• Synonyms: NKL; NPHP7

Reference Data