SREBP2 (SREBF2) Rabbit Polyclonal Antibody

SKU TA349060

Rabbit Polyclonal Anti-SREBF2 Antibody

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SREBF2 antibody was raised against a 15 amino acid peptide near the center of human SREBF2.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SREBF2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 126 kDa; Observed: 128 kDa
• Gene Name: sterol regulatory element binding transcription factor 2
• Database Link:
  NP_004590
  Q12772
• Background: The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1,2). The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2). SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3).
• Synonyms: bHLHd1; SREBP-1c; SREBP1; SREBP1a

Reference Data