TET1 Rabbit Polyclonal Antibody

CAT#: TA349033

Rabbit Polyclonal Anti-TET1 Antibody

Product Images

Western blot analysis of TET1 in rat brain tissue lysate with TET1 antibody at (A) 1 and (B) 2ug/ml.

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  Immunocytochemistry of TET1 in mouse brain tissue with TET1 antibody at 5ug/ml.

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  Immunohistochemistry of TET1 in human brain tissue with TET1 antibody at 5ug/ml.

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  Immunofluorescence of TET1 in human brain tissue with TET1 antibody at 20ug/ml.

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  Immunofluorescence of TET1 in mouse brain tissue with TET1 antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TET1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET1. The immunogen is located within amino acids 2030 - 2080 of TET1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TET1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 235 kDa; Observed: 240 kDa
• Gene Name: tet methylcytosine dioxygenase 1
• Database Link:
  NP_085128
  Entrez Gene 52463 MouseEntrez Gene 309902 RatEntrez Gene 80312 Human
  UniProt ID Q8NFU7
• Background: TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t(10;11)(q22;q23) (1). It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2). TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3). Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4).
• Synonyms: bA119F7.1; CXXC6; LCX