HIRA Rabbit Polyclonal Antibody

SKU TA347137

Rabbit Polyclonal Hira Antibody

Product Data

• Application: ELISA, WB
• Recommended Dilution: ELISA (1:100 ?? 1:200) ; Western blotting (1:1,000)
• Reactivity: Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Hira antibody: mouse Hira (histone cell cycle regulation defective homolog A), using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein
• Concentration: lot specific
• Purification: Whole antiserum from rabbit containing 0.05% azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: histone cell cycle regulator
• Database Link:
  NP_003316
  P54198
• Background: Hira (UniProtKB/Swiss-Prot entry P54198) is a histone chaperone that cooperates with ASF1A to promote replication-independent chromatin assembly. It is important for histone regulation and is required for the periodic repression of histone gene transcription during the cell cycle. Hira plays an important role in the formation of transcriptionally silent senescence-associated heterochromatic foci (SAHF). SAHF, which contain heterochromatin proteins such as HP1, are believed to repress expression of proliferation-promoting genes, leading to the irreversible cell cycle changes that occur in senescent cells. Interaction between HIRA and ASF1A is the rate limiting step in the formation of SAHF. Hira is also thought to be involved in certain haploinsufficiency syndromes such as DiGeorge syndrome. Insufficient production of Hira protein may disrupt normal embryonic development.
• Synonyms: DGCR1; TUP1; TUPLE1

Reference Data

• Protein Families: Transcription Factors