KIAA1967 (CCAR2) Mouse Monoclonal Antibody [Clone ID: 3G4-D11-D7]

CAT#: TA346986

Mouse Monoclonal DBC1 Antibody

Specifications

Product Data

• Clone Name: 3G4-D11-D7
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1:500, IF: 1:200
• Reactivities: Human, Mouse, Rat, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for KIAA1967 antibody: purified recombinant human DBC1 protein fragments expressed in E.coli
• Formulation: Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 130 kDa
• Gene Name: cell cycle and apoptosis regulator 2
• Database Link:
  NP_066997
  Entrez Gene 219158 MouseEntrez Gene 306007 RatEntrez Gene 57805 Human
  UniProt ID Q8N163
• Background: Core component of the DBIRD complex,a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing:the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions.Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.Inhibits SUV39H1 methyltransferase activity.As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
• Synonyms: DBC-1; DBC1; KIAA1967; NET35; p30 DBC; p30DBC