NLRX1 Rabbit Polyclonal Antibody

SKU TA337151

Rabbit Polyclonal NLRX1 Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: Immunohistochemistry, Western Blot: 5-7ug/ml~, Immunohistochemistry-Paraffin: 5-10ug/ml
• Reactivity: Equine, Human, Mouse, Primate, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acid 580-630 of human NLRX1 was used as the immunogen for the antibody.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: NLR family member X1
• Database Link:
  NP_078894
  Q86UT6
• Background: NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
• Synonyms: CLR11.3; DLNB26; NOD5; NOD9; NOD26

Reference Data

• Protein Pathways: RIG-I-like receptor signaling pathway