GFI1 Rabbit Polyclonal Antibody

SKU TA337145

Rabbit Polyclonal GFI-1 Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: Immunohistochemistry, Western Blot: 6-8ug/ml~, Immunohistochemistry-Paraffin: 5ug/ml
• Reactivity: Bovine, Chicken, Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acid 280-330 of human Zinc finger protein Gfi-1 was used as the immunogen.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: growth factor independent 1 transcriptional repressor
• Database Link:
  NP_005254
  Q99684
• Background: Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.
• Synonyms: GFI-1; GFI1A; SCN2; ZNF163

Reference Data

• Protein Families: Druggable Genome, Transcription Factors