DECTIN 2 (CLEC6A) Mouse Monoclonal Antibody [Clone ID: 3D1]

SKU TA337142

Mouse Monoclonal Dectin-2/CLEC6A Antibody (3D1)

Product Data

• Clone Name: 3D1
• Application: CyTOF-ready, FC, IHC, WB
• Recommended Dilution: Immunohistochemistry-Paraffin: 1:200, Immunohistochemistry: 1:200, Flow (Cell Surface), CyTOF-ready, Western Blot: 2 - 5ug/mL, Flow Cytometry: 0.5 ug/5x10^5 cells
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG3, kappa
• Clonality: Monoclonal
• Immunogen: A portion of amino acids 75-139 of human Dectin-2 was used as the immunogen for the antibody. 90-106
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: C-type lectin domain family 6 member A
• Database Link:
  NP_001007034
  Q6EIG7
• Background: Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcR 7; for internalization and to activate NF-kB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.
• Synonyms: CLEC4N; CLECSF10

Reference Data

• Protein Families: Transmembrane