Calreticulin (CALR) Rabbit Polyclonal Antibody

SKU TA336667

Rabbit Polyclonal Calreticulin Antibody

Product Data

• Application: Block/Neutralize, Dot, Electron Microscopy, FC, ICC/IF, IHC, IP, Protein Array, Simple Western, WB
• Recommended Dilution: Protein Array, Immunoprecipitation, Flow Cytometry, Knockdown Validated: 1:1500, Western Blot: 1:1000, Simple Western: 1:50, Immunohistochemistry: 1:50 - 1:200, Immunohistochemistry-Paraffin: 1:50 -1:200, Immunocytochemistry/ Immunofluorescence: 1:50-1:250, Block/Neutralize, Dot Blot, Electron Microscopy
• Reactivity: Bovine, Hamster, Human, Mouse, Primate, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A fusion protein to mouse Calreticulin [UniProt# P14211]
• Buffer: PBS, 30% glycerol, 0.1% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: calreticulin
• Database Link:
  NP_004334
  P27797
• Background: Calreticulin is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER). It is also a molecular chaperone and is involved in protein folding events in the ER. Calreticulin has also been shown to interact with the cytoskeleton and to be involved in the regulation of gene expression. Calreticulin may play a role in cellular proliferation including its apparent activity in the proliferation of certain viruses within mammalian host cells. (2-3) Recently it has been shown that calreticulin is induced in response to various types of cell stress including amino acid deprivation. (1) Close interconnections among protein synthesis, gene expression and calcium signaling have been observed by many researchers in recent years. Calreticulin might be centrally located and crucially participate in the coordination of these functions by the cell.(2-3)
• Synonyms: cC1qR; CRT; HEL-S-99n; RO; SSA
• Note: This Calreticulin antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry and Western blot, where a band is observed at ~55 kDa. Electron Microscopy, Blocking/Neutralizing, Dot Blot, Immunoprecipitation and Protein Array were reported in scientific literature.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transcription Factors
• Protein Pathways: Antigen processing and presentation