MCM6 Rabbit Polyclonal Antibody

CAT#: TA327220

Rabbit anti-MCM6 Polyclonal Antibody

Product Images

Western blot analysis of extracts of 293 cell lines, using MCM6 antibody.

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  Immunofluorescence analysis of U2OS cell using MCM6 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human MCM6
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: minichromosome maintenance complex component 6
• Database Link:
  NP_005906
  Entrez Gene 17219 MouseEntrez Gene 29685 RatEntrez Gene 4175 Human
  UniProt ID Q14566
• Background: The MCM genes were firstly identified in yeast defective in minichromosome maintenance and have since been shown to have roles in the progression of the cell cycle, and most of them are cell division control genes. MCM2-7 complex are suggested to be DNA licensing factors which bind to the DNA after mitosis and enable DNA replication before being removed during S phase. Mini-chromosome maintenance 6 (MCM6) is one component of the MCM2-7 complex which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. MCM6 single subunit forms homohexamer and contains an ATP-dependent and replication fork stimulated 3 to 5 DNA unwinding activity along with intrinsic DNA-dependent ATPase and ATP-binding activities.
• Synonyms: MCG40308; Mis5; P105MCM

Reference Data

• Protein Families: Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Cell cycle, DNA replication