Tau tubulin kinase 2 (TTBK2) Rabbit Polyclonal Antibody

CAT#: TA326601

Rabbit Polyclonal TTBK2 Antibody

Product Images

Immunohistochemistry of TTBK2 in human placenta tissue with TTBK2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2.
• Formulation: TTBK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TTBK2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tau tubulin kinase 2
• Database Link:
  AAH71556
  Entrez Gene 146057 Human
  UniProt ID Q6IQ55
• Background: TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
• Synonyms: SCA11; TTBK