Caspr (CNTNAP1) Mouse Monoclonal Antibody [Clone ID: S65-35]

SKU TA326340

Mouse monoclonal CASPR Antibody

Product Data

• Clone Name: S65-35
• Application: IHC, WB
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivity: Human, Mouse, Rat
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein 1308-1381 (cytoplasmic domain) of rat CASPR
• Buffer: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: contactin associated protein 1
• Database Link:
  NP_003623
  P78357
• Background: Caspr (contactin-associated protein) is a part of the neurexin family. It lies in the paranodal section of the myelin sheath. Its role is for myelin sheath attachment along with contactin in a cis-complex . Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction, whereas Caspr serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region. Both interact with protein 4.1B .
• Synonyms: CASPR; CNTNAP; NRXN4; P190
• Note: Detects ~220kDa.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)