Caspr (CNTNAP1) Mouse Monoclonal Antibody [Clone ID: S65-35]
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USD 200.00
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Specifications
Product Data | |
Clone Name | S65-35 |
Applications | IHC, WB |
Recommended Dilution | WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Fusion protein 1308-1381 (cytoplasmic domain) of rat CASPR |
Formulation | PBS pH7.4, 50% glycerol |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | contactin associated protein 1 |
Database Link | |
Background | Caspr (contactin-associated protein) is a part of the neurexin family. It lies in the paranodal section of the myelin sheath. Its role is for myelin sheath attachment along with contactin in a cis-complex . Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction, whereas Caspr serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region. Both interact with protein 4.1B . |
Synonyms | CASPR; CNTNAP; NRXN4; P190 |
Note | Detects ~220kDa. |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs) |
Documents
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