COX11 Rabbit Polyclonal Antibody

SKU TA323960

Anti-COX11 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 1000-5000; WB positive control: Mouse brain tissue; IHC: 25-100; Positive control: Human stomach cancer; Predicted cell location: Cytoplasm, Cell membrane
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 115-276 amino acids of human cytochrome c oxidase assembly homolog 11 (yeast)
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 31 kDa
• Gene Name: COX11 cytochrome c oxidase copper chaperone
• Database Link:
  NP_001156333
  Q9Y6N1
• Background: Cytochrome c oxidase (COX); the terminal component of the mitochondrial respiratory chain; catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer; and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit; but may be a heme A biosynthetic enzyme involved in COX formation; according to the yeast mutant studies. However; the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis; but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.?
• Synonyms: COX11P

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Metabolic pathways, Oxidative phosphorylation