LIFR Rabbit Polyclonal Antibody

SKU TA323028

Anti-LIFR Rabbit Polyclonal Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 25-100; Positive control: Human colon cancer; Predicted cell location: Cytoplasm, Nucleus
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 115-128 amino acids of Human leukemia inhibitory factor receptor alpha
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: leukemia inhibitory factor receptor alpha
• Database Link:
  NP_002301
  P42702
• Background: This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit; gp130; to form a receptor complex that mediates the action of the leukemia inhibitory factor; a polyfunctional cytokine that is involved in cellular differentiation; proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2; a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene; t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1; is associated with salivary gland pleiomorphic adenoma; a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
• Synonyms: CD118; LIF-R; SJS2; STWS; SWS

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway