SLC22A17 Rabbit Polyclonal Antibody
Anti-SLC22A17 Rabbit Polyclonal Antibody
Product Datasheet for 'TA322261'
|Recommend Dilution||ELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:25-100|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide corresponding to a region derived from 511-524 amino acids of human solute carrier family 22, member 17|
|Formulation||PBS pH7.3, 0.05% NaN3, 50% glycerol|
|Purification||Antigen affinity purification|
|Predicted Protein Size||56kDa|
|Gene Name||solute carrier family 22 member 17|
|Background||Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3); followed by internalization of holo-24p3 and release of iron; thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3); followed by internalization of apo-24p3 and its association with an intracellular siderophore; leading to iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration and resulting in apoptosis.|
|Protein Families||Transmembrane, Druggable Genome|
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