SLC22A17 Rabbit Polyclonal Antibody
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Transient overexpression lysate of solute carrier family 22, member 17 (SLC22A17), transcript variant 2
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Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 500-2000 WB positive control: Human esophagus cancer tissue IHC: 25-100 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 511-524 amino acids of human solute carrier family 22, member 17 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 56 kDa |
Gene Name | solute carrier family 22 member 17 |
Database Link | |
Background | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3); followed by internalization of holo-24p3 and release of iron; thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3); followed by internalization of apo-24p3 and its association with an intracellular siderophore; leading to iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration and resulting in apoptosis. |
Synonyms | 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Documents
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.