Tropomyosin 2 (TPM2) Rabbit Polyclonal Antibody

CAT#: TA321952

Anti-TPM2 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 40 μg Lane: Human cervical cancer tissue Primary antibody: TA321952 (TPM2 Antibody) at dilution 1/600 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321952 (TPM2 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321952 (TPM2 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human cervical cancer tissue
  IHC: 50-200
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 188-207 amino acids of Human tropomyosin 2 (beta)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 33 kDa
• Gene Name: tropomyosin 2 (beta)
• Database Link:
  NP_998839
  Entrez Gene 7169 Human
  UniProt ID P07951
• Background: This gene encodes beta-tropomyosin; a member of the actin filament binding protein family; and mainly expressed in slow; type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins; and cause cap disease; nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. TPM2 has been shown to interact with RRAD; PDLIM7 and TPM1.
• Synonyms: AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB

Reference Data

• Protein Pathways: Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)