CDC42 Rabbit Polyclonal Antibody

CAT#: TA321400

Anti-Cdc42/Rho/Rac Rabbit Polyclonal Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane: Human fetal brain tissue Primary antibody: TA321400 (Cdc42/RhoA/Rac1 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 minutes

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human fetal brain tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 57-71 amino acids of Human Cell division cycle 42
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 23 kDa
• Gene Name: cell division cycle 42
• Database Link:
  NP_001782
  Entrez Gene 12540 MouseEntrez Gene 64465 RatEntrez Gene 998 Human
  UniProt ID P60953
• Background: The protein encoded by this gene is a small GTPase of the Rho-subfamily; which regulates signaling pathways that control diverse cellular functions including cell morphology; migration; endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42; and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP); which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
• Synonyms: CDC42Hs; G25K

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Axon guidance, Chemokine signaling pathway, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Fc gamma R-mediated phagocytosis, Focal adhesion, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Tight junction, VEGF signaling pathway