CMYA5 Rabbit Polyclonal Antibody

CAT#: TA320142

Rabbit Polyclonal SPRYD2 Antibody

Product Images

Western blot analysis of SPRYD2 in rat brain tissue lysate with SPRYD2 antibody at (A) 1 and (B) 2 ug/mL

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  Immunohistochemistry of SPRYD2 in mouse brain tissue with SPRYD2 antibody at 2.5 ug/mL.

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  Immunofluorescence of SPRYD2 in mouse brain tissue with SPRYD2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SPRYD2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SPRYD2.
• Formulation: SPRYD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: SPRYD2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cardiomyopathy associated 5
• Database Link:
  NP_705838
  Entrez Gene 76469 MouseEntrez Gene 688915 RatEntrez Gene 202333 Human
  UniProt ID Q8N3K9
• Background: SPRYD2 Antibody: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
• Synonyms: C5orf10; SPRYD2; TRIM76

Reference Data

• Protein Families: Druggable Genome