KREMEN2 Rabbit Polyclonal Antibody

SKU TA320011

Rabbit Polyclonal KREMEN2 Antibody

Product Data

• Application: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .
• Buffer: KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Purification: KREMEN2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 51 kDa; Observed: 54 kDa
• Gene Name: kringle containing transmembrane protein 2
• Database Link:
  NP_757384
  Q8NCW0
• Background: KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
• Synonyms: kringle-containing transmembrane protein 2; kringle containing transmembrane protein 2; KRM2; MGC10791; MGC16709

Reference Data