Rsafd1 (TYW1) Rabbit Polyclonal Antibody

CAT#: TA319957

Rabbit Polyclonal TYW1 Antibody

Product Images

Western blot analysis of TYW1 in human lung tissue lysate with TYW1 antibody at 1 ug/mL.

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  Immunohistochemistry of TYW1 in human lung tissue with TYW1 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TYW1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TYW1.
• Formulation: TYW1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TYW1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tRNA-yW synthesizing protein 1 homolog
• Database Link:
  NP_060734
  Entrez Gene 304423 RatEntrez Gene 55253 Human
  UniProt ID Q9NV66
• Background: TYW1 Antibody: TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions
• Synonyms: RSAFD1; TYW1A; YPL207W

Reference Data

• Protein Families: Transmembrane