TMEM59 Rabbit Polyclonal Antibody

CAT#: TA319781

Rabbit Polyclonal TMEM59 Antibody

Product Images

Western blot analysis of TMEM59 in human kidney tissue lysate with TMEM59 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of TMEM59 in human kidney tissue with TMEM59 antibody at 2.5 ug/mL.

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  Immunofluorescence of TMEM59 in human kidney tissue with TMEM59 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59.
• Formulation: TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TMEM59 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transmembrane protein 59
• Database Link:
  NP_004863
  Entrez Gene 9528 Human
  UniProt ID Q9BXS4
• Background: TMEM59 Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
• Synonyms: C1orf8; DCF1; HSPC001; PRO195; UNQ169

Reference Data

• Protein Families: Transmembrane