CENPE Mouse Monoclonal Antibody [Clone ID: 1H12]

SKU TA319576

Mouse monoclonal anti-CENP-E antibody

Product Data

• Clone Name: 1H12
• Application: IF
• Recommended Dilution: ELISA: 1:5,000 - 1:20,000, WB: 1:500 - 1:2,000, IF: 1:500 - 1:2,000, IP: 1:200
• Reactivity: Human
• Antibody Host: Mouse
• Clonality: Monoclonal
• Immunogen: This protein A purified monoclonal antibody was produced by repeated immunizations with a full length recombinant protein corresponding to human CENP-E protein.
• Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: centromere protein E
• Database Link:
  NP_001804
  Q02224
• Synonyms: CENP-E; KIF10; MCPH13; PPP1R61
• Note: CENP-E, Centrosome-associated protein E, is a kinesin-like minus-end directed microtubule motor protein that accumulates in the G₂ phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometa-phase. CENP-E is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. CENP-E interacts with CENP-F and BUBR1 kinase. CENP-E associates with kinetochores during congression, relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency