ROBO1 Rabbit Polyclonal Antibody

CAT#: TA319298

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Rabbit polyclonal anti-ROBO-1 antibody



USD 530.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution ELISA: 1:30,000 - 1:160,000, WB: 1:500 - 1:3,000, IHC: 2 ug/ml to 10 ug/ml, IF: User Optimized
Reactivity Human, Mouse, Rat, Dog
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1632-1644 of Human ROBO-1.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration 1 mg/ml
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name roundabout guidance receptor 1
Synonyms DUTT1; SAX3
Note ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2. The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein. ROBO-1 is a widely expressed protein with the exception of the kidney. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.
Reference Data
Protein Families Druggable Genome
Protein Pathways Axon guidance
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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