Thyroid Peroxidase (TPO) Goat Polyclonal Antibody

CAT#: TA309510

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Goat Polyclonal Antibody against thyroid peroxidase



USD 375.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB 0.3-1ug/ml; IHC 5-10ug/ml
Reactivity Human
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence C-TRHVIQVSNEVVTDD, from the internal region of the protein sequence according to NP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1.
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name thyroid peroxidase
Background This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq]
Synonyms MSA; TDH2A; TPX
Note IHC: In paraffin embedded Human Thyroid Gland shows textured staining in the cytoplasm of epithelial cells.
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Metabolic pathways, Tyrosine metabolism
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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