STAM1 (STAM) Rabbit Polyclonal Antibody

SKU TA308964

Rabbit Polyclonal antibody to STAM (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1)

Product Data

• Application: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivity: Bovine, Human (Predicted: Mouse, X. tropicalis), Xenopus
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 16 and 326 of STAM (Uniprot ID#Q92783)
• Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 59 kDa
• Gene Name: signal transducing adaptor molecule
• Database Link:
  NP_003464
  Q92783
• Background: This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein. [provided by RefSeq]
• Synonyms: STAM-1; STAM1
• Note: Seq homology of immunogen across species: Mouse (96%), Xenopus laevis (88%), Bovine (97%), Xenopus tropicalis (90%)

Reference Data

• Protein Pathways: Endocytosis, Jak-STAT signaling pathway