Lamin A (LMNA) Rabbit Polyclonal Antibody

CAT#: TA308920

Rabbit Polyclonal antibody to Lamin A/C (lamin A/C)

Product Images

Lamin A/C antibody detects LMNA protein by Western blot analysis. A. 30 ug NIH-3T3 whole cell lysate/extract. 7.5 % SDS-PAGE. Lamin A/C antibody (TA308920) dilution: 1:1000

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  Sample (20 ug ). A: HeLa Nucleus. 10% SDS PAGE. TA308920 diluted at 1:3000.

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  Immunohistochemical analysis of paraffin-embedded H441 Xenograft, using Lamin A/C (TA308920) antibody at 1:100 dilution.

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  Lamin A/C antibody detects Lamin A/C protein at nuclear envelope on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. Lamin A/C antibody (TA308920) dilution: 1:500.

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  Lamin A/C antibody detects Lamin A/C protein at nuclear envelope on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. Lamin A/C antibody (TA308920) dilution: 1:500.

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Chimpanzee)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment contain a sequence corresponding to a region within amino acids 59 and 572 of Lamin A/C
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 65 kDa
• Gene Name: lamin A/C
• Database Link:
  NP_733822
  Entrez Gene 4000 Human
  UniProt ID P02545
• Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]
• Synonyms: CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC
• Note: Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)