RGS14 Rabbit Polyclonal Antibody

CAT#: TA308383

Rabbit Polyclonal antibody to RGS14 (regulator of G-protein signaling 14)

Product Images

RGS14 antibody [C3], C-term detects RGS14 protein by Western blot analysis. A. 30 ug Jurkat whole lysate/extract. 7.5 % SDS-PAGE. RGS14 antibody [C3], C-term (TA308383) dilution: 1:500

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  Immunohistochemical analysis of paraffin-embedded GASTRIC CA, using RGS14 (TA308383) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 504 and 566 of RGS14 (Uniprot ID#O43566)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 61 kDa
• Gene Name: regulator of G-protein signaling 14
• Database Link:
  NP_006471
  Entrez Gene 10636 Human
  UniProt ID O43566
• Background: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]
• Synonyms: regulator of G-protein signaling 14; regulator of G-protein signalling 14

Reference Data

• Protein Families: Druggable Genome