GAD65 (GAD2) Rabbit Polyclonal Antibody
Rabbit Polyclonal antibody to GAD65 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa))
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:10000 |
Reactivity | Human, Mouse (Predicted: Rhesus Monkey) |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant fragment corresponding to a region within amino acids 353 and 585 of GAD65 (Uniprot ID#Q05329) |
Formulation | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
Purification | Purified by antigen-affinity chromatography. |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 65 kDa |
Gene Name | glutamate decarboxylase 2 |
Database Link | |
Background | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq] |
Synonyms | GAD65 |
Note | Seq homology of immunogen across species: Rhesus Monkey (100%) |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Fine Mapping of Glutamate Decarboxylase 65 Epitopes Reveals Dependency on Hydrophobic Amino Acids for Specific Interactions
,Valdarnini, N;Holm, B;Hansen, P;Rovero, P;Houen, G;Trier, N;,
Int J Mol Sci 2019
,PubMed ID 31207885
[GAD65]
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